Publications
The evidence behind PROMEDX.
A 28-publication peer-reviewed evidence base anchored by a long-running prospective multi-center trial demonstrating that quantitative liver function predicts clinical outcomes.
Years of research support PROMEDX starting with the landmark HALT-C and A2ALL clinical trials funded by the National Institutes of Health. Subsequent clinical research on the etiology, diagnosis, prognosis and complications of liver disease have culminated in physiologic staging which provides insights into the health of the liver not available from fibrosis staging.
1
Perfused Kupffer Cell Mass: Correlation with Histology and Severity of Chronic Liver Disease
John Hoefs MD, et al, Digestive Diseases and Sciences, Vol 40, No. 3, March 1995.
2
Functional Measurement of Non-fibrotic Hepatic Mass in Cirrhotic Patients
Hoefs JC, Wang F, and Kanel G; American Journal of Gastroenterology, Vol 92, 2054-2058, 1997.
3
A Novel, Simple Method of Functional Spleen Volume Calculation by Liver-Spleen Scan
Hoefs JC, Wang F, Lilien D, Walker B, and Kanel B; Journal of Nuclear Medicine, Vol 40:1745-55, 1999.
4
Factors Affecting the Quantitative Liver–Spleen Scan in Normal Individuals
Hoefs JC, Sheikh MY, Guerrero H, and Milne N; Digestive Diseases and Sciences, Vol. 50, pp 283-289, 2005.
5
The Spectrum of Hepatic Functional Impairment in Compensated Chronic Hepatitis C: Results from the HALT-C Trial
Everson et al. — Alimentary Pharmacology & Therapeutics, Vol. 27, 2008
6
Quantitative Tests of Liver Function Measure Hepatic Improvement after Sustained Virologic Response
Everson GT, Shiffman ML, Hoefs JC, et al., HALT-C Trial Group — Aliment. Pharmacol. Ther., Vol. 29, pp. 589–601, 2009
7
Quantitative Liver Function Tests Improve the Prediction of Clinical Outcomes in Chronic Hepatitis C
Everson GT, Shiffman ML, Hoefs JC, et al. — Hepatology, 2012; 55: 1019–1029
8
Functional Elements Associated with Hepatic Regeneration in Living Donors after Right Hepatic Lobectomy
Everson, Hoefs, Niemann, Olthoff, Dupuis, Lauriski, Herman, Milne, Gillespie, Goodrich, Everhart — Liver Transplantation, Vol. 19, No. 3, 2013
9
HEPATIQ Measure of Hepatic Function: Range in Function for Ascites & Death in Patients with Chronic Liver Disease
Hoefs JC — Journal of Hepatology, Vol. 64, S213–S424, 2016
10
Physiologic Staging in Alcoholic Liver Disease Predicts Death and Monitors Recovery
Hoefs JC — EASL, The International Liver Congress, 2017
11
Steatohepatitis: Differential Features on Quantitative Liver-Spleen Scan (QLSS)
Hoefs JC — EASL, The International Liver Congress, 2017
12
Shear Wave Elasticity (SWE) Unreliable in Detection of Cirrhosis
Hoefs JC — AASLD, The Liver Meeting, 2018
13
Physiologic Staging with HEPATIQ Predicts Cirrhosis Better Than Shear Wave Elasticity
Hoefs JC — AASLD, The Liver Meeting, 2018
14
Small Liver Volumes: Cause and Significance
Hoefs JC — The Liver Meeting, Hepatology, October 2019
15
Quantitative Hepatic Function Predicts Time to Death After Diagnosis of Hepatocellular Carcinoma (HCC)
Hoefs JC — Digestive Disease Week, 2020
16
Liver Surface Nodularity as an Estimate of Quantitative Liver Function and Portal Hypertension
Hoefs JC — Digestive Disease Week, 2020
17
Is Physiologic Staging of Chronic Liver Disease Possible with Ultrasound?
Hoefs JC — AASLD, The Liver Meeting, 2020
18
Quantitative Liver Spleen Scan Can Predict the Outcome in Patients with Alcoholic Hepatitis
Hashim MA, Ismail MS, Moore WH, Hassan MM, Hoefs J, Jalal P — AASLD, The Liver Meeting, 2020
19
HEPATIQ Predicts Cirrhosis and Decompensation
Hoefs JC — AASLD, The Liver Meeting, 2021
20
HEPATIQ Predicts Decompensation for Cirrhotics
Hoefs JC, Ghosh D — AASLD, The Liver Meeting, 2021
21
Large Functional Liver Volume (fLV) and ATI Combined in the Diagnosis of Steatohepatitis
Hoefs JC — Digestive Disease Week, 2022
22
The Functional Liver Volume (fLV) by HEPATIQ is Superior to ATI in the Diagnosis of Steatohepatitis
Hoefs JC, Basta N, Ghosh D — Society of Nuclear Medicine and Molecular Imaging, 2022
23
HAI by HEPATIQ: Marker for ALD or for Alcoholic Hepatitis?
Hoefs JC — AASLD, The Liver Meeting, 2022
24
Revolutionizing Care in Cirrhotic Patients Using HEPATIQ in a Community Setting
Huynh T, Lyche B, Lyche K — AASLD, The Liver Meeting, 2022
25
Hemodynamic Measurement of Quantitative Liver Function by HEPATIQ Detects CLD and Differentiates from Acute Causes of Jaundice
Hoefs JC — Digestive Disease Week, 2023
26
NASH Cirrhosis: The Intra-Hepatic Hemodynamic Abnormality (IHHA) Measured Baseline and Change Over Time Predicts Clinical Outcomes and Survival
Hoefs JC — The Liver Meeting, 2023
27
SPECT Identifies Compensated Cirrhotics with Higher Accuracy than Blood Tests
Ghosh D, Hoefs JC — Asian Pacific Association for the Study of the Liver, 2024
28
Hoefs Physiologic System (H) for Reporting the Results of the Quantitative Liver-Spleen Scan (QLSS) as Processed by HEPATIQ
Hoefs JC — Society of Nuclear Medicine and Molecular Imaging, 2024
Comparative analysis references
A
Liver Disease Diagnostics Market Research Report, Global Forecast to 2027
360iResearch, December 2022
B
Ability of Noninvasive Scoring Systems to Identify Individuals in the Population at Risk for Severe Liver Disease
Hagström H, Talbäck M, Andreasson A, Walldius G, Hammar N — Gastroenterology, 2020 Jan;158(1):200–214
C
Accuracy of Noninvasive Fibrosis Scores to Detect Advanced Fibrosis in Patients with Type-2 Diabetes with Biopsy-proven NAFLD
Singh A, Gosai F, Siddiqui MT, et al. — J. Clin. Gastroenterol., 2020;54(10):891–897
D
The Importance of Liver Functional Reserve in the Non-surgical Treatment of Hepatocellular Carcinoma
D’Avola D, Granito A, de la Torre-Aláez M, Piscaglia F — Journal of Hepatology, 2022